Are you getting the following error in your mail logs?
R=hubbed_hosts T=remote_smtp defer (-53): retry time not reached for any host
Fedora users try this
james@spork [/] mv /var/spool/exim/db /var/spool/exim/db_backup
james@spork [/]rm /var/spool/exim/db
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thannnnk yooouuuuuuuu
I’m on debian with exim4 and the same errors and this solved lots of my errors
Glad I could help